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The sequencing datasets (raw sequence files can be found at: were aligned to the human reference genome GRCh38 22 and 22036 unique RNA features were mapped

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An alarming 90% of the global population is exposed to contaminated air, resulting in approximately seven million deaths annually (Zacarias and Grubert, 2021)

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This Perspective is part of the topical collection: Environmental effects of stratospheric ozone depletion, UV radiation, and interactions with climate change: UNEP Environmental Effects Assessment Panel, 2022 Quadrennial Assessment ( 2 New knowledge about mechanisms underpinning the effects of UV radiation on health 2.1 Genes and skin cancer Skin cancer arises primarily as a consequence of UV-induced DNA damage that remains unrepaired, combined with immune suppression (Fig